6 years have passed since the biological disaster in Raccoon City.

Leon S. Kennedy, one of the survivors of the incident, has been recruited as an agent reporting directly to the president of the United States.

With the experience of multiple missions on his back, Leon is sent to rescue the president's kidnapped daughter. He tracks her to a secluded European village, where there is something terribly wrong with the villagers. And the curtain rises on this story of daring rescue and grueling horror.